Format

Send to

Choose Destination
See comment in PubMed Commons below
J Theor Biol. 2013 Dec 7;338:87-93. doi: 10.1016/j.jtbi.2013.08.019. Epub 2013 Aug 30.

Computer simulation of voltage sensitive calcium ion channels in a dendritic spine.

Author information

  • 1Department of Physiology and Biotechnology and Bioengineering Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. Electronic address: leep@cims.nyu.edu.

Abstract

Membrane current through voltage-sensitive calcium ion channels at the postsynaptic density of a dendritic spine is investigated. To simulate the ion channels that carry such current and the resulting temporal and spatial distribution of concentration, current, and voltage within the dendritic spine, the immersed boundary method with electrodiffusion is applied. In this simulation method a spatially continuous chemical potential barrier is used to simulate the influence of the membrane on each species of ion. The amplitudes of these barriers can be regulated to simulate channel gating. Here we introduce this methodology in a one-dimensional setting. First, we study the current-voltage relationship obtained with fixed chemical potential barriers. Next, we simulate stochastic ion-channel gating in a calcium channel with multiple subunits, and observe the diffusive wave of calcium entry within the dendritic spine that follows channel opening. This work lays the foundation for future three-dimensional studies of electrodiffusion and advection electrodiffusion in dendritic spines.

© 2013 Elsevier Ltd. All rights reserved.

KEYWORDS:

Continuous-time Markov process; Current–voltage relationship; Electrodiffusion; The immersed boundary method

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk