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Allergy Asthma Proc. 2013 Sep-Oct;34(5):473-9. doi: 10.2500/aap.2013.34.3672.

Recurrent fevers and failure to thrive in an infant.

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  • 1Scripps Clinic, Department of Medicine, San Diego, CA 92130, USA.


We describe a 2-year old boy with consanguineous parents who recently emigrated from India and presented with oral ulcers and lymphadenopathy. He also had a history of recurrent fevers, polyarticular arthritis, chronic diarrhea, failure to thrive, and developmental delay. Infectious workup revealed herpes simplex virus 1 viremia and radiological evaluation revealed osteopenia and erosions involving multiple joints. We describe the immunologic and genetic evaluation of this patient and discuss the diagnostic and therapeutic approach to an infant with recurrent fevers.

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