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Adv Mater. 2013 Dec 3;25(45):6569-74. doi: 10.1002/adma.201303124. Epub 2013 Sep 1.

Carbon nanodots featuring efficient FRET for real-time monitoring of drug delivery and two-photon imaging.

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  • 1Laboratory of Advanced Materials Department of Chemistry, Fudan University, Shanghai, 200433, China.

Abstract

A FRET-based carbon nanodot (CDot) drug delivery platform has been developed. These CDots offer excellent biocompatibility, stable fluorescence, and efficient FRET between CDots and the attached fluorescent drug molecules, such as doxorubicin, enabling enhanced drug delivery, convenient cell imaging, and real-time monitoring of drug release. Moreover, the FRET-based two-photon imaging and drug tracking in deep tissues are also demonstrated.

© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KEYWORDS:

FRET; carbon nanodots; cytotoxicity; drug delivery; monitoring; two-photon imaging

PMID:
23996326
[PubMed - indexed for MEDLINE]
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