Send to

Choose Destination
See comment in PubMed Commons below
Clin Pediatr Endocrinol. 2013 Apr;22(2):33-8. doi: 10.1292/cpe.22.33. Epub 2013 Apr 26.

Development of endometrial carcinoma in a patient with leprechaunism (donohue syndrome).

Author information

  • 1Department of Pediatrics, Hokkaido University School of Medicine, Hokkaido, Japan ; Department of Pediatrics, Sapporo City Hospital, Hokkaido, Japan.


Leprechaunism is a rare autosomal recessive disease that is characterized by severe insulin resistance. This disease is caused by a defective insulin receptor and features abnormal glucose metabolism and retarded intrauterine and postnatal growth. However, there are few reports on the long-term course of leprechaunism. We reported the long-term clinical course and rh-IGF-1 treatment in a patient with leprechaunism. During follow-up her diabetes gradually deteriorated despite of treatment of rh-IGF-1. Furthermore, she developed endometrioid adenocarcinoma at the age of 24 yr. The development of endometrial disease must be carefully followed up in this disease.


Leprechaunism; endometrioid adenocarcinoma; insulin receptor; rh-IGF-1

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk