Abstract
A water-soluble fluorescent probe for Hg(2+) based on a rhodamine B derivative was designed and synthesized. The new probe showed reversible colorimetric and fluorescent response to Hg(2+) in a fully aqueous solution. The probe exhibited real-time detection of Hg(2+) with high selectivity in media containing less than 1% organic cosolvent. Furthermore, bioimaging studies indicated that the new probe was cell permeable and suitable for the real-time imaging of Hg(2+) in living cells by confocal microscopy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Survival
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Colorimetry
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Crystallography, X-Ray
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Fluorescence
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry*
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HeLa Cells
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Humans
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Hydrogen-Ion Concentration
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Mercury / analysis*
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Models, Molecular
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Molecular Structure
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Rhodamines / chemical synthesis
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Rhodamines / chemistry*
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Solubility
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Spectrometry, Fluorescence
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Spectrophotometry, Ultraviolet
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Water / chemistry
Substances
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Fluorescent Dyes
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Rhodamines
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Water
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Mercury
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rhodamine B