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Chin Med J (Engl). 2013 Aug;126(16):3073-8.

Neovascularization in the carotid atherosclerotic plaque is not associated with inflammatory cell aggregation.

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  • 1Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China.

Abstract

BACKGROUND:

Monocytes and macrophages in atherosclerotic plaque lead to plaque instability. The aim of the study was to determine if plaque neovascularization led to inflammation.

METHODS:

Patients were consecutively enrolled if their carotid intimal media thickness was > 2 mm, as revealed by duplex ultrasound. The patients then underwent dynamic contrast enhanced magnetic resonance imaging (DCE MRI) and fluorine-18 fluorodeoxyglucose ((18)F-FDG) positron emission tomography combined with computed tomography (PET CT). A target to background ratio (TBR) of ≥ 1.25 or < 1.25 served as the cutoff point for the presence and absence of inflammation, respectively.

RESULTS:

Twenty-six patients underwent bilateral carotid DCE MRI and 24 patients also underwent PET CT. One hundred and fifty-five plaques were evaluated by both DCE MRI and PET CT. There was no significant difference in plaque morphology between the TBR ≥ 1.25 (n = 61) and TBR < 1.25 (n = 94) groups. No significant differences were found in plasma volume and transfer constant between the TBR ≥ 1.25 and TBR < 1.25 groups.

CONCLUSION:

Our study did not find a significant correlation between plaque neovascularization and the aggregation of inflammatory cells.

PMID:
23981615
[PubMed - indexed for MEDLINE]
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