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Cancer Lett. 2014 Apr 10;345(2):216-22. doi: 10.1016/j.canlet.2013.08.035. Epub 2013 Aug 25.

Hepatitis B virus-induced hepatocellular carcinoma.

Author information

  • 1Institute for Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
  • 2The Department of General Surgery II, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.
  • 3Institute for Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. Electronic address: wym417@163.com.
  • 4Storr Liver Unit, University of Sydney, Westmead Millennium Institute, Westmead Hospital, Westmead, NSW 2145, Australia. Electronic address: liang.qiao@sydney.edu.au.

Abstract

Many factors are considered to contribute to hepatitis B virus (HBV) associated hepatocellular carcinoma (HCC), including products of HBV, HBV integration and mutation, and host susceptibility. HBV X protein (HBx) can interfere with several signal pathways that associated with cell proliferation and apoptosis, and the impact of HBx C-terminal truncation in the development of HCC has been implicated. Recent studies by advanced sequencing technologies have revealed recurrent HBV DNA integration sites in hepatoma cells and susceptible genes/SNPs play an important role in the pathogenesis of liver cancer. Epigenetic changes, immune and inflammatory factors are also important contributing factors for liver cancer. This mini-review provides an overview on the recent development of HBV induced HCC.

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Carcinogenesis; HBV; HBVx; HCC

PMID:
23981576
[PubMed - indexed for MEDLINE]
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