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Cancer Lett. 2014 Jan 1;342(1):27-35. doi: 10.1016/j.canlet.2013.08.033. Epub 2013 Aug 24.

MiR-215 modulates gastric cancer cell proliferation by targeting RB1.

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  • 1The Center for Diseases Modeling, and Program in Molecular Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.

Abstract

Growing evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. Here, we report that miR-215 is significantly up-regulated in gastric cancer tissues from either gastrectomy or gastroscopy. Receiver Operator Characteristic (ROC) curve analysis indicated that miR-215 may be a candidate biomarker for gastric cancer diagnosis. Inhibition of miR-215 significantly suppressed gastric cancer cell proliferation possibly via G1 arrest. Further analyses indicated that miR-215 was able to target retinoblastoma tumor-suppressor gene 1 (RB1) through its 3'-UTR in gastric cancer cells. These data suggest that frequently up-regulated miR-215 in gastric cancer may influence cell proliferation by targeting RB1.

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Gastric cancer; MiR-215; Proliferation; Retinoblastoma

PMID:
23981575
[PubMed - indexed for MEDLINE]
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