Format

Send to:

Choose Destination
See comment in PubMed Commons below
Adv Biomed Res. 2013 Mar 30;2:35. doi: 10.4103/2277-9175.109721. eCollection 2013.

Cancer problem in Peutz-Jeghers syndrome.

Author information

  • 1Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

Peutz-Jeghers syndrome is a rare autosomal dominantly inherited condition, characterized by the presence of hamartomatous gastrointestinal polyps and mucocutaneous pigmentation. Patients with this syndrome can be associated with other neoplasms such as ovarian neoplasms known as sex-cord tumor with annular tubules that are associated in one third of the cases with this syndrome and other types of malignancies. We report a 42-year-old woman with a history of Peutz-Jeghers Syndrome and bilateral breast cancer that presented with abnormal uterine bleeding. Total abdominal hysterectomy with bilateral salpino-oophorectomy was done and an ovarian sex cord tumor with annular tubules was incidentally diagnosed. By reviewing literatures and in agreement with previous studies we suggest routine screening for malignancies in patients with Peutz-Jeghers syndrome.

KEYWORDS:

Breast cancer; Peutz–Jeghers syndrome; ovarian cancer; sex cord tumor

PMID:
23977663
[PubMed]
PMCID:
PMC3748667
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Medknow Publications and Media Pvt Ltd Icon for PubMed Central
    Loading ...
    Write to the Help Desk