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Age Ageing. 2013 Nov;42(6):803-9. doi: 10.1093/ageing/aft126. Epub 2013 Aug 23.

Prognosis of hospitalised older people with different levels of functioning: a prospective cohort study.

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  • 1Erasmus University Medical Center-Public Health, Dr. Molewaterplein 50 3015 GE, Rotterdam, Netherlands.



hospitalised older people are at risk for poor functioning after hospital discharge. We aimed to validate the predictive ability of the Identification Seniors At Risk-Hospitalized Patients (ISAR-HP) screening questionnaire to identify older patients at risk for functional dependence by comparing groups with different ISAR-HP scores on cognitive and physical functioning, mortality, health-related quality of life (HRQoL) and loneliness.


a longitudinal prospective cohort study.


a 450-bed hospital in the Netherlands.


four hundred and sixty patients 65 years or older admitted between June 2010 and October 2010.


participants were classified into five risk groups at hospital admission using the ISAR-HP. We interviewed patients at hospital admission and at 3 and 12 months after admission using validated questionnaires to score HRQoL, physical functioning, cognitive functioning and loneliness. Differences in survival were quantified by a concordance statistic (c).


cognitive functioning, physical functioning, loneliness and HRQoL differed significantly between groups during the 1-year follow-up after hospital admission (all comparisons P < 0.05), with high-risk groups having lower scores than low-risk groups for functioning and loneliness, although not always for HRQoL. The lowest risk group (ISAR-HP = 0) scored consistently higher on functioning and HRQoL than all other groups. Mortality differed significantly between groups (P < 0.001, c = 0.67).


the ISAR-HP can readily distinguish well-functioning older patients from patients with low functioning and low HRQoL after hospital admission. The ISAR-HP may hence assist in selecting patients who may benefit from individually tailored reactivation treatment that is provided next to treatment of their medical condition.


HRQoL; functioning; mortality; older patients; older people

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