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Pediatr Blood Cancer. 2014 Feb;61(2):233-7. doi: 10.1002/pbc.24745. Epub 2013 Aug 23.

Comparison of Latino and non-Latino patients with Ewing sarcoma.

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  • 1Department of Pediatrics, San Francisco School of Medicine, University of California, San Francisco, California; Department of Pathology, San Francisco School of Medicine, University of California, San Francisco, California.

Abstract

BACKGROUND:

Ewing sarcoma (ES) is a malignancy of bone and soft tissue in children and adults. Previous registry-based studies indicate that Latino patients with ES have inferior outcomes compared to non-Latino patients, though an etiology for this difference could not be identified. To explore possible differences that might underlie this disparity, we conducted a retrospective study to compare clinical characteristics, tumor features, healthcare access, and treatment outcomes between Latino and non-Latino patients with ES.

METHODS:

Primary data for 218 ES patients treated at two academic medical centers between 1980 and 2010 were collected. Categorical data were compared using Fisher exact tests; Wilcoxon rank-sum tests were used for continuous variables. Survival was estimated using Kaplan-Meier analysis and compared using log-rank testing.

RESULTS:

Latino patients were diagnosed at a younger age (P = 0.014). All other clinical and histological data were similar between groups, including radiologic and histologic response to neoadjuvant chemotherapy. Latino patients had lower socioeconomic status (P = 0.001), were less likely to have insurance (P = 0.001), and were more likely to present to the emergency room at onset of symptoms (P = 0.031) rather than to primary care physicians. Five-year event free survival (EFS) and overall survival (OS) were similar between Latino and non-Latino patients (EFS: 60.5% vs. 50.9% P = 0.37; OS: 77.6% vs. 68.6% P = 0.54).

CONCLUSION:

Latino patients with ES present at a younger age, and have evidence of impaired access to healthcare. Response to initial therapy appears similar between Latino and non-Latino patients.

© 2013 Wiley Periodicals, Inc.

KEYWORDS:

Ewing sarcoma; Latino; cancer disparities; ethnicity; hispanic

PMID:
23970433
[PubMed - indexed for MEDLINE]
PMCID:
PMC4206264
Free PMC Article
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