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J Pediatr. 2013 Dec;163(6):1578-1584.e4. doi: 10.1016/j.jpeds.2013.07.004. Epub 2013 Aug 20.

Associations of preterm births with child health and development: Japanese population-based study.

Author information

  • 1Department of Public Health and Public Policy, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address: goose@hiroshima-u.ac.jp.

Abstract

OBJECTIVE:

To examine associations between the duration of gestation and health and development outcomes at 2.5 years and 5.5 years using a Japanese population-based longitudinal survey (n = 47 015).

STUDY DESIGN:

Hospitalization was used as an indicator of physical health, and responses to questions about age-appropriate behaviors were used as an indicator of behavioral development. We conducted logistic regression analyses controlling for a set of neonatal and family factors. We also estimated population-attributable fractions.

RESULTS:

We observed a steady increase toward shorter duration of gestation in the risk of hospitalizations at age 2.5 years and 5.5 years and developmental delays at 2.5 years (Plinear trend < .001 for all outcomes). We found associations only between extremely preterm birth and delayed behavioral development at age 5.5 years.

CONCLUSION:

There is a linear relationship between shorter duration of gestation and increased risk of later health and developmental problems. In line with Rose's "population paradox," the population-attributable risks for these problems are greater for moderately preterm infants compared with extremely preterm infants.

Copyright © 2013 Mosby, Inc. All rights reserved.

KEYWORDS:

MHLW; Ministry of Health, Labour, and Welfare; PAF; Population-attributable fraction

PMID:
23968745
[PubMed - indexed for MEDLINE]
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