Abstract
Human α defensins human neutrophil peptide 1-3 (HNP 1-3) are potential prognostic cancer biomarkers. Metalloprotein anthrax lethal factor (ALF) binds to HNP 1-3 in a Zn2+-dependent manner. We conjugated ALF to the surface of magnetic nanoparticles (MNP) to magnetically isolate the HNPs, and used Zn2+ to control the capture and release HNPs.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, Bacterial / chemistry*
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Antigens, Bacterial / metabolism
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Bacterial Toxins / chemistry*
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Bacterial Toxins / metabolism
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Biomarkers / analysis
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Biomarkers / blood
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Chromatography, High Pressure Liquid
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Ferrosoferric Oxide / chemistry
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Humans
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Magnetite Nanoparticles / chemistry*
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Saliva / metabolism*
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization*
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Tears / metabolism*
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Zinc / chemistry
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alpha-Defensins / analysis*
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alpha-Defensins / blood
Substances
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Antigens, Bacterial
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Bacterial Toxins
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Biomarkers
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Magnetite Nanoparticles
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alpha-Defensins
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anthrax toxin
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human neutrophil peptide 1
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Zinc
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Ferrosoferric Oxide