Histamine H(4) receptor antagonists ineffective against itch and skin inflammation in atopic dermatitis mouse model

J Invest Dermatol. 2014 Feb;134(2):546-548. doi: 10.1038/jid.2013.351. Epub 2013 Aug 20.

Authors

Atsuko Kamo¹, Osamu Negi¹, Suhandy Tengara¹, Yayoi Kamata¹, Atsushi Noguchi¹, Hideoki Ogawa¹, Mitsutoshi Tominaga¹, Kenji Takamori²

Affiliations

¹ Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan.
² Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan; Department of Dermatology, Juntendo University Urayasu Hospital, Chiba, Japan. Electronic address: ktakamor@juntendo.ac.jp.

PMID: 23962807
DOI: 10.1038/jid.2013.351

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dermatitis, Atopic / drug therapy*
Dermatitis, Atopic / physiopathology
Disease Models, Animal
Indoles / pharmacology*
Male
Mice
Mice, Inbred Strains
Piperazines / pharmacology*
Pruritus / drug therapy*
Pruritus / physiopathology
Receptors, G-Protein-Coupled / antagonists & inhibitors*
Receptors, Histamine
Receptors, Histamine H4
Treatment Failure

Substances

Hrh4 protein, mouse
Indoles
Piperazines
Receptors, G-Protein-Coupled
Receptors, Histamine
Receptors, Histamine H4
1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine