Abstract
A new furanone metabolite of the rubrolide family, rubrolide R as diacetate (1), was isolated from a new species of the ascidian Synoicum, besides the known compounds rubrolide A (as diacetate), cadiolide B and prunolide A. The structure of the new rubrolide was elucidated by a study of spectral data. The crude extract and isolated compounds (prunolide A and cadiolide B) showed antiviral activity against the Japanese encephalitis virus. Prunolide A showed cytotoxic activity against breast cancer cell lines at a concentration of < 1 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Antiviral Agents / chemistry
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Antiviral Agents / isolation & purification*
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Antiviral Agents / pharmacology
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Drug Screening Assays, Antitumor
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Encephalitis Virus, Japanese / drug effects
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Female
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Furans / chemistry
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Furans / isolation & purification*
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Furans / pharmacology
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Humans
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Indian Ocean
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Molecular Structure
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Urochordata / chemistry*
Substances
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Antineoplastic Agents
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Antiviral Agents
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Furans
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rubrolide R