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World J Nucl Med. 2013 Jan;12(1):48-50. doi: 10.4103/1450-1147.113966.

Excessive Hepatic Arterial-portal Venous Shunting May Predict Failure of Microparticle Localization in Hepatocellular Carcinomas.

Author information

  • 1Department of Nuclear Medicine and PET, Singapore General Hospital, Outram, Singapore.

Abstract

Locoregional treatment of hepatocellular carcinomas using yttrium-90 (Y-90) microspheres is an emerging modality, and involves the administration of such radioactive particles directly into the hepatic arterial vasculature. We present the case of a 58-year-old gentleman undergoing evaluation for Y-90 microsphere therapy for hepatocellular carcinoma, in which our findings suggest that significant hepatic arterial portal venous shunting detected during the angiogram maybe a predictor of poor localization of microspheres in the turmor, and that centers that utilize body surface area (BSA) approaches for dosimetry should take note of such findings.

KEYWORDS:

Hepatocellular carcinoma; Y-90 microsphere therapy; arteria-portal venous shunting

PMID:
23961258
[PubMed]
PMCID:
PMC3745636
Free PMC Article

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