Format

Send to

Choose Destination
See comment in PubMed Commons below
JAMA Neurol. 2013 Oct;70(10):1249-53.

Salience network resting-state activity: prediction of frontotemporal dementia progression.

Abstract

IMPORTANCE:

Noninvasive measures of activity within intrinsic brain networks may be clinically relevant, providing a marker of neurodegenerative disease and predicting clinical behaviors.

OBJECTIVE:

To correlate baseline resting-state measures within the salience network and changes in behavior among patients with frontotemporal dementia.

DESIGN:

Baseline resting-state functional magnetic resonance imaging data and longitudinal clinical measures were obtained from prospectively accrued patients during 8 weeks.

SETTING:

Tertiary academic care center specializing in the assessment and management of patients with neurodegenerative disease.

PARTICIPANTS:

Fifteen patients with clinically diagnosed frontotemporal dementia (5 behavioral variant and 10 semantic dementia).

MAIN OUTCOMES AND MEASURES:

Baseline resting-state functional magnetic resonance imaging data measured within regions of interest were regressed on serial behavioral measures from prospectively accrued patients with frontotemporal dementia to determine the ability of baseline resting-state activity to account for changes in behavior.

RESULTS:

Low-frequency fluctuations in the left insula significantly predicted changes in Frontal Behavioral Inventory scores (standard β = 0.51, P = .049), accounting for 28% of the change variance. The trend was driven by changes in measures of apathy independent of dementia severity.

CONCLUSION AND RELEVANCE:

Baseline measures of salience network connectivity involving the left insula may predict behavioral changes in patients with frontotemporal dementia.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Write to the Help Desk