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    Proc Natl Acad Sci U S A. 1990 Sep;87(17):6833-7.

    Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens.

    Szala S, Kasai Y, Steplewski Z, Rodeck U, Koprowski H, Linnenbach AJ.

    Source

    Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.

    Abstract

    The human tumor-associated antigen CO-029 is a monoclonal antibody-defined cell surface glycoprotein of 27-34 kDa. By using the high-efficiency COS cell expression system, a full-length cDNA clone for CO-029 was isolated. When transiently expressed in COS cells, the cDNA clone directed the synthesis of an antigen reactive to monoclonal antibody CO-029 in mixed hemadsorption and immunoblot assays. Sequence analysis revealed that CO-029 belongs to a family of cell surface antigens that includes the melanoma-associated antigen ME491, the leukocyte cell surface antigen CD37, and the Sm23 antigen of the parasitic helminth Schistosoma mansoni. CO-029 and ME491 antigen expression and the effect of their corresponding monoclonal antibodies on cell growth were compared in human tumor cell lines of various histologic origins.

    PMID:
    2395876
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC54632
    Free PMC Article

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