-
- Comment in:
-
Nature. 1990 Sep 6;347(6288):21-2.
Atomic structure of the actin:DNase I complex.
Max-Planck-Institut für medizinische Forschung, Abteilung Biophysik, Heidelberg, FRG.
The atomic models of the complex between rabbit skeletal muscle actin and bovine pancreatic deoxyribonuclease I both in the ATP and ADP forms have been determined by X-ray analysis at an effective resolution of 2.8 A and 3A, respectively. The two structures are very similar. The actin molecule consists of two domains which can be further subdivided into two subdomains. ADP or ATP is located in the cleft between the domains with a calcium ion bound to the beta- or beta- and gamma-phosphates, respectively. The motif of a five-stranded beta sheet consisting of a beta meander and a right handed beta alpha beta unit appears in each domain suggesting that gene duplication might have occurred. These sheets have the same topology as that found in hexokinase.
PMID: 2395459 [PubMed - indexed for MEDLINE]
-
Cited by over 100 PubMed Central articles
-
Problems in fitting high resolution structures into electron microscopic reconstructions.
Egelman EH.
HFSP J. 2008 Dec; 2(6):324-31. Epub 2008 Sep 29.
[HFSP J. 2008]
-
Actomyosin interaction: mechanical and energetic properties in different nucleotide binding States.
Aprodu I, Redaelli A, Soncini M.
Int J Mol Sci. 2008 Oct; 9(10):1927-43. Epub 2008 Oct 13.
[Int J Mol Sci. 2008]
-
Phenotypes induced by NM causing alpha-skeletal muscle actin mutants in fibroblasts, Sol 8 myoblasts and myotubes.
Vandamme D, Lambert E, Waterschoot D, Tondeleir D, Vandekerckhove J, Machesky LM, Constantin B, Rommelaere H, Ampe C.
BMC Res Notes. 2009 Mar 10; 2:40. Epub 2009 Mar 10.
[BMC Res Notes. 2009]
- » See all...
Structures reported by this article