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Adv Healthc Mater. 2014 Mar;3(3):313-31. doi: 10.1002/adhm.201300221. Epub 2013 Aug 15.

Solution-gated graphene transistors for chemical and biological sensors.

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  • 1Department of Applied Physics and Materials Research Center, The Hong Kong Polytechnic University Kowloon, Hong Kong, China.


Graphene has attracted much attention in biomedical applications for its fascinating properties. Because of the well-known 2D structure, every atom of graphene is exposed to the environment, so the electronic properties of graphene are very sensitive to charged analytes (ions, DNA, cells, etc.) or an electric field around it, which renders graphene an ideal material for high-performance sensors. Solution-gated graphene transistors (SGGTs) can operate in electrolytes and are thus excellent candidates for chemical and biological sensors, which have been extensively studied in the recent 5 years. Here, the device physics, the sensing mechanisms, and the performance of the recently developed SGGT-based chemical and biological sensors, including pH, ion, cell, bacterial, DNA, protein, glucose sensors, etc., are introduced. Their advantages and shortcomings, in comparison with some conventional techniques, are discussed. Conclusions and challenges for the future development of the field are addressed in the end.

© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


biosensors; chemical sensors; graphene; transistors

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