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Clin Pharmacol Ther. 2013 Nov;94(5):562-5. doi: 10.1038/clpt.2013.164. Epub 2013 Aug 14.

Pharmacometabolomics of statin response.

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  • 1Children's Hospital Oakland Research Institute, Oakland, California, USA.

Abstract

Statins reduce risk of cardiovascular disease (CVD) by decreasing plasma low-density lipoprotein (LDL) concentrations, as well as reducing inflammation and improving endothelial function. Despite their documented efficacy, there is considerable interindividual variation in effects of statins on CVD biomarkers. In the studies summarized here, we used complementary metabolomics platforms to define global effects of a statin (simvastatin) on metabolism and to identify markers indicative of mechanisms that contribute to variation in plasma LDL response to statin treatment.

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