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J Org Chem. 2013 Sep 6;78(17):8267-73. doi: 10.1021/jo4014589. Epub 2013 Aug 20.

Sesterterpenoids isolated from a northeastern Pacific Phorbas sp.

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  • 1Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1.


Four new sesterterpenoids, ansellone B (4), phorbadione (5), secoepoxyansellone A (6), and alotaketal C (7), have been isolated from specimens of the sponge Phorbas sp. collected in British Columbia. Ansellone B (4) has an unprecedented heterocyclic skeleton featuring an oxocane ring, and secoepoxyansellone A (6) is the first example of the degraded "secoansellane" sesterterpenoid carbon skeleton. Alotaketal C (7) is an activator of cAMP signaling in HEK cells.

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