Format

Send to:

Choose Destination
See comment in PubMed Commons below
BJU Int. 2014 Feb;113(2):236-45. doi: 10.1111/bju.12287. Epub 2013 Aug 13.

A cohort study of digoxin exposure and mortality in men with prostate cancer.

Author information

  • 1Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin, Ireland.

Abstract

OBJECTIVE:

To examine the association between digoxin exposure and mortality in men with prostate cancer using linked Irish National Cancer Registry and pharmacy claims data.

PATIENTS AND METHODS:

Prostate cancer cases were identified from the database and digoxin exposure at prostate cancer diagnosis was identified from prescription claims. Digoxin users were matched to non-users using a propensity score to identify men with similar cardiovascular comorbidity. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for the association between digoxin exposure and all-cause and prostate cancer-specific mortality (PCSM). Analyses were repeated in the propensity score-matched cohort. Effect modification of treatment with radiation or androgen-deprivation therapy by digoxin exposure was also assessed.

RESULTS:

In all, 5732 men with a prostate cancer diagnosis (2001-2006) were identified (digoxin exposed, 391). The median follow-up was 4.3 years. Digoxin exposure was associated with a small non-significant increase in PCSM in the full cohort (HR 1.13, 95% CI 0.91, 1.42) and the propensity. score-matched cohort (HR 1.17, 95% CI 0.88, 1.57). Adjusted HRs for all-cause mortality were increased for digoxin exposed men (HR 1.24, 95% CI 1.07, 1.43). Interactions with treatments received were not significant.

CONCLUSIONS:

These results suggest digoxin exposure is not associated with reduced PCSM. Further investigation of other cardiac glycosides that have shown anti-cancer potential may be warranted.

© 2013 The Authors. BJU International © 2013 BJU International.

KEYWORDS:

cardiac glycoside; digoxin; hypoxia-inducible factor 1α; mortality; propensity score; prostate neoplasms

PMID:
23937513
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk