Immune regulation by CD52-expressing CD4 T cells

Cell Mol Immunol. 2013 Sep;10(5):379-82. doi: 10.1038/cmi.2013.35. Epub 2013 Aug 12.

Abstract

T-cell regulation by CD52-expressing CD4 T cells appears to operate by two different and possibly synergistic mechanisms. The first is by its release from the cell surface of CD4 T cells that express high levels of CD52 that then binds to the inhibitory sialic acid-binding immunoglobulin-like lectins-10 (Siglec-10) receptor to attenuate effector T-cell activation by impairing phosphorylation of T-cell receptor associated lck and zap-70. The second mechanism appears to be by crosslinkage of the CD52 molecules by an as yet unidentified endogenous ligand that is mimicked by a bivalent anti-CD52 antibody that results in their expansion.

MeSH terms

  • Animals
  • Antibodies / pharmacology
  • Antigens, CD / genetics
  • Antigens, CD / immunology*
  • Antigens, Neoplasm / genetics
  • Antigens, Neoplasm / immunology*
  • CD4-Positive T-Lymphocytes / cytology
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / metabolism
  • CD52 Antigen
  • Cell Proliferation / drug effects
  • Cytokines / genetics
  • Cytokines / immunology
  • Gene Expression Regulation / immunology*
  • Glycoproteins / agonists
  • Glycoproteins / genetics
  • Glycoproteins / immunology*
  • Humans
  • Lectins / genetics
  • Lectins / immunology
  • Lymphocyte Activation / drug effects
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / genetics
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / immunology
  • Mice
  • Receptors, Antigen, T-Cell / agonists
  • Receptors, Antigen, T-Cell / genetics
  • Receptors, Antigen, T-Cell / immunology*
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / immunology
  • Signal Transduction
  • T-Lymphocytes, Regulatory / cytology
  • T-Lymphocytes, Regulatory / immunology*
  • T-Lymphocytes, Regulatory / metabolism
  • ZAP-70 Protein-Tyrosine Kinase / genetics
  • ZAP-70 Protein-Tyrosine Kinase / immunology

Substances

  • Antibodies
  • Antigens, CD
  • Antigens, Neoplasm
  • CD52 Antigen
  • CD52 protein, human
  • Cytokines
  • Glycoproteins
  • Lectins
  • Receptors, Antigen, T-Cell
  • Receptors, Cell Surface
  • SIGLEC10 protein, human
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
  • ZAP-70 Protein-Tyrosine Kinase