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Life Sci. 2013 Oct 10;93(15):516-24. doi: 10.1016/j.lfs.2013.07.027. Epub 2013 Aug 8.

The inhibitory effect of naringenin on atopic dermatitis induced by DNFB in NC/Nga mice.

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  • 1Department of Microbiology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.



Atopic dermatitis (AD) is a chronic and relapsing inflammatory dermatitis characterized by pruritic and eczematous skin lesions. Here, we investigated the therapeutic effect of the fruit flavonoid naringenin on DNFB induced atopic dermatitis mice model.


AD-like skin lesion was induced by repetitive skin contact with DNFB in NC/Nga mice and the effects of the fruit flavonoid naringenin were evaluated on the basis of histopathological findings of skin, ear swelling and cytokine production of CD4(+)T cells.


Intraperitoneal injection of naringenin for one week after DNFB challenge significantly lowered ear swelling and improved back skin lesions. In addition, naringenin significantly suppressed production of interferon-gamma (IFN-γ) by activated CD4(+) T cells and serum IgE level. Furthermore, naringenin reduced DNFB-induced infiltration of eosinophils, mast cells, CD4(+) T cells, and CD8(+) T cells in skin lesions.


Naringenin may suppress the development of AD-like skin lesions in DNFB-treated NC/Nga mice by reducing IFN-γ production of activated CD4(+) T cells, serum IgE levels and infiltration of immune cells to skin lesion.

© 2013.


2,4-dinitrofluorobenzene; Atopic dermatitis; NC; Naringenin; Nga mice; Skin barrier

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