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Comput Methods Programs Biomed. 2013 Oct;112(1):104-13. doi: 10.1016/j.cmpb.2013.05.029. Epub 2013 Aug 7.

Computer-aided diagnosis system: a Bayesian hybrid classification method.

Author information

  • 1Department of Mathematics, Faculty of Veterinary Medicine, University of Extremadura, Avda. de la Universidad s/n, 10003 Cáceres, Spain. Electronic address: fcalonso@unex.es.

Abstract

A novel method to classify multi-class biomedical objects is presented. The method is based on a hybrid approach which combines pairwise comparison, Bayesian regression and the k-nearest neighbor technique. It can be applied in a fully automatic way or in a relevance feedback framework. In the latter case, the information obtained from both an expert and the automatic classification is iteratively used to improve the results until a certain accuracy level is achieved, then, the learning process is finished and new classifications can be automatically performed. The method has been applied in two biomedical contexts by following the same cross-validation schemes as in the original studies. The first one refers to cancer diagnosis, leading to an accuracy of 77.35% versus 66.37%, originally obtained. The second one considers the diagnosis of pathologies of the vertebral column. The original method achieves accuracies ranging from 76.5% to 96.7%, and from 82.3% to 97.1% in two different cross-validation schemes. Even with no supervision, the proposed method reaches 96.71% and 97.32% in these two cases. By using a supervised framework the achieved accuracy is 97.74%. Furthermore, all abnormal cases were correctly classified.

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Bayesian methodology; Classification; Computer-aided diagnosis; Relevance feedback

PMID:
23932384
[PubMed - indexed for MEDLINE]
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