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J Clin Neurosci. 2013 Nov;20(11):1546-9. doi: 10.1016/j.jocn.2013.02.014. Epub 2013 Aug 6.

Surgical treatment options and management strategies of metastatic renal cell carcinoma to the lumbar spinal nerve roots.

Author information

  • 1Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02115, USA.

Abstract

Spinal nerve root metastasis of renal cell carcinoma is a rare occurrence. In addition to treatment of the primary lesion, surgical resection of the nerve root metastasis, occasionally with sacrifice of the involved nerve, is the accepted standard of treatment. Resection often resolves presenting motor and pain symptoms due to relief of neural compression. We describe two patients with nerve root metastasis of renal cell carcinoma and their management. While locally advanced and metastatic renal cell carcinoma has been shown to be chemo- and radio-resistant, immunotherapy is a promising treatment. Given the high prevalence of systemic disease in patients with intradural metastases, systemic (and possibly intracranial) imaging can be used to identify other potential areas of disease.

Copyright © 2013 Elsevier Ltd. All rights reserved.

KEYWORDS:

Cauda equina; Intradural; Metastasis; Nerve root; Renal; Spine

PMID:
23931936
[PubMed - indexed for MEDLINE]
PMCID:
PMC3805749
[Available on 2014/11/1]
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