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Clin Lab Med. 2013 Sep;33(3):629-50. doi: 10.1016/j.cll.2013.03.005.

Bacterial strain typing.

Author information

  • 1National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road Northeast, MS-C12, Atlanta, GA 30333, USA. dmaccannell@cdc.gov

Abstract

Over the course of the past several decades, rapid advancements in molecular technologies have revolutionized the practice of public health microbiology, and have fundamentally changed the nature, accuracy, and timeliness of laboratory data for outbreak investigation and response. Whole-genome sequencing, in particular, is becoming an increasingly feasible and cost-effective approach for near real-time high-resolution strain typing, genomic characterization, and comparative analyses. This review discusses the current state of the art in bacterial strain typing for outbreak investigation and infectious disease surveillance, and the impact of emerging genomic technologies on the field of public health microbiology.

Published by Elsevier Inc.

KEYWORDS:

Bacterial typing techniques; DNA sequence analysis; Genomics; Molecular epidemiology; Multilocus sequence typing; Pulsed-field gel electrophoresis

PMID:
23931842
[PubMed - indexed for MEDLINE]
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