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Clin Microbiol Infect. 2014 Jan;20(1):O20-6. doi: 10.1111/1469-0691.12321. Epub 2013 Aug 9.

Four-year epidemiological study of extended-spectrum β-lactamase-producing Enterobacteriaceae in a French teaching hospital.

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  • 1Laboratoire de Bactériologie, CHU Clermont-Ferrand, Centre de Biologie, Clermont-Ferrand, France; Microbes, Intestins, Inflammation et Susceptibilité de l'Hôte, INSERM U1071, INRA, USC2018, Clermont Université, Université d'Auvergne, Clermont-Ferrand, France.


Since the end of the last century resistance to oxyimino β-lactams has steadily increased in Enterobacteriaceae. In the present work we studied extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae strains isolated in the teaching hospital of Clermont-Ferrand, France, between 2006 and 2009. A total of 1368 ESBL-producing isolates were collected. Most of these isolates (69%) were CTX-M-producing Escherichia coli. During the study, the clinical incidence increased by more than 400%, even in the emergency department, and especially in community-acquired infections, as is the case elsewhere in the world. Most of the ESBL-producing isolates remained susceptible to furans and fosfomycin, but only 50% to fluoroquinolons. In conclusion, ESBL-producing bacteria constantly increased during the study period. Unlike many studies, this increase was associated with the wide dissemination of three different CTX-M enzymes: CTX-M-14, CTX-M-15 and CTX-M-1.

© 2013 The Authors Clinical Microbiology and Infection © 2013 European Society of Clinical Microbiology and Infectious Diseases.


Antibiotic resistance; Enterobacteriaceae; Escherichia coli; extended-spectrum β-lactamase; β-lactamase

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