Format

Send to:

Choose Destination
See comment in PubMed Commons below
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2013 Aug;30(4):451-5. doi: 10.3760/cma.j.issn.1003-9406.2013.04.016.

[Association of single nucleotide polymorphism of methylenetetrahydrofolate reductase gene with susceptibility to acute leukemia].

[Article in Chinese]

Author information

  • 1Institute of Pediatrics Research, Shenzhen Children's Hospital, Zunyi Medical College, Shenzhen, Guangdong 518026, P. R. China. lijieyue@yahoo.com.

Abstract

OBJECTIVE:

To assess whether polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene is associated with susceptibility to acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML) in Chinese Han children.

METHODS:

The study has included 87 patients with ALL, 22 patients with AML and 120 healthy controls. All subjects were analyzed with reverse transcriptase-polymerase chain reaction-denaturing gradient gel electrophoresis and sequencing.

RESULTS:

A 677CT genotype of the MTHFR gene was associated with decreased risk of ALL (OR=0.23, 95%CI: 0.07-0.79). However, MTHFR A1298C genotypes were not associated with the risk of either disease. 677TT/1298AA and 677CC/1298AC genotypes were associated with increased risk of ALL(OR=3.78, 95% CI: 1.38-10.40; OR=3.17, 95% CI: 1.18-8.53, respectively), whereas the genotype 677CT/1298AA was associated with susceptibility to AML (OR=0.23, 95% CI: 0.06-0.97).

CONCLUSION:

Our data suggested that C677T polymorphism of MTHFR gene may increase the risk of childhood AML.

PMID:
23926015
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk