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J Invest Dermatol. 2014 Feb;134(2):366-73. doi: 10.1038/jid.2013.334. Epub 2013 Aug 7.

Propionibacterium acnes Induces an IL-17 Response in Acne Vulgaris that Is Regulated by Vitamin A and Vitamin D.

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  • 1Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
  • 21] Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA [2] Department of Dermatology, College of Medicine, Dankook University, Seoul, South Korea.
  • 3Department of Medicine Statistics Core, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
  • 41] Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA [2] Department of Dermatology, Greater Los Angeles Healthcare System Veterans Affairs, Los Angeles, California, USA.

Abstract

Acne vulgaris is the most common skin disorder affecting millions of people worldwide and inflammation resulting from the immune response targeting Propionibacterium acnes has a significant role in its pathogenesis. In this study, we have demonstrated that P. acnes is a potent inducer of T helper 17 (Th17) and Th1, but not Th2 responses in human peripheral blood mononuclear cells (PBMCs). P. acnes stimulated expression of key Th17-related genes, including IL-17A, RORα, RORc, IL-17RA, and IL-17RC, and triggered IL-17 secretion from CD4(+), but not from CD8(+) T cells. Supernatants from P. acnes-stimulated PBMCs were sufficient to promote the differentiation of naive CD4(+)CD45RA T cells into Th17 cells. Furthermore, we found that the combination of IL-1β, IL-6, and transforming growth factor-β-neutralizing antibodies completely inhibited P. acnes-induced IL-17 production. Importantly, we showed that IL-17-expressing cells were present in skin biopsies from acne patients but not from normal donors. Finally, vitamin A (all-trans retinoic acid) and vitamin D (1,25-dihydroxyvitamin D3) inhibited P. acnes-induced Th17 differentiation. Together, our data demonstrate that IL-17 is induced by P. acnes and expressed in acne lesions and that both vitamin A and D could be effective tools to modulate Th17-mediated diseases such as acne.

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PMID:
23924903
[PubMed - indexed for MEDLINE]
PMCID:
PMC4084940
Free PMC Article

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