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Neurology. 2013 Sep 10;81(11):944-5. doi: 10.1212/WNL.0b013e3182a43e93. Epub 2013 Aug 6.

Hunting for autoantibodies in multiple sclerosis.

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  • 1From the Department of Neurology (B.H., R.S.), Klinikum rechts der Isar, Technische Universit√§t M√ľnchen; Munich Cluster for Systems Neurology (SyNergy) (B.H.); and German Competence Network Multiple Sclerosis (KKNMS) (B.H.), Munich, Germany.

Abstract

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the CNS. Many findings support the assumption that the immune system plays a key role in the pathogenesis of MS, at least during the relapsing-remitting phase of disease.(1,2) Both arms of the adapted immune response seem to be crucial for the induction and maintenance of the autoimmune response as suggested by the success of therapies targeting T cells, B cells, or both. While genes and pathways involved in the pathogenesis of MS have emerged from recent studies, the molecular targets of the autoimmune response in MS are still largely uncertain. The identification of these targets, to better understand the pathogenesis and develop specific immune therapies, has been the focus of MS research during the last decades.

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