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Bioorg Med Chem. 2013 Sep 15;21(18):5782-93. doi: 10.1016/j.bmc.2013.07.016. Epub 2013 Jul 17.

Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity.

Author information

  • 1Department of Pharmaceutical Technology, National Institute of Pharmaceutical Education and Research, Mohali, S.A.S. Nagar, Punjab, India.

Abstract

Design, synthesis and anticancer activity of a series of imine-pyrazolopyrimidinones is reported for the first time. Compounds 9d, 9n and 9o in the series show encouraging in vitro anticancer activity with low micromolar IC50 values against prostate (PC3) and breast (MCF7) cancer cell lines. Some notions about structure-activity relationships and plausible mechanism of biological activity are presented.

Copyright © 2013 Elsevier Ltd. All rights reserved.

KEYWORDS:

Anticancer agents; Catalytic topoisomerase inhibitors; Effects on G2/M phase of the cell cycle; Imine-pyrazolopyrimidinones; Synthesis

PMID:
23920485
[PubMed - indexed for MEDLINE]
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