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J Nat Prod. 2013 Aug 23;76(8):1509-13. doi: 10.1021/np400232j. Epub 2013 Aug 5.

Phoslactomycins from Streptomyces sp. MLA1839 and their biological activities.

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  • 1Discovery Research, Dow AgroSciences , 9330 Zionsville Road, Indianapolis, Indiana 46268, USA. SFotso@dow.com


Phoslactomycins H (1) and I (2), two new members of the phoslactomycin class of chemistry, were isolated from Streptomyces sp. MLA1839 on the basis of their antifungal activities. Their structures were elucidated using extensive NMR spectroscopy and mass spectrometry. Phoslactomycin H (1) featured a rare and unprecedented N,N-dimethylamine substitution at C-4 and existed as a hydroxy acid rather than the more common lactone. Herein, we report the structure of these compounds and their biological activities.

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