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Adv Mater. 2013 Nov 6;25(41):5869-74. doi: 10.1002/adma.201301338. Epub 2013 Aug 5.

Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops: a new tool for the measurement of cell traction forces transmitted through αvβ3- or α5β1-integrins.

Author information

  • 1Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Heisenbergstr. 3, 70569, Stuttgart, Germany; Department of Biophysical Chemistry, University of Heidelberg, Im Neuenheimer Feld 253, 69120, Heidelberg, Germany.

Abstract

Poly(ethylene glycol) micropillars with gold nanopatterns on top are functionalized with two integrin selective ligands. This platform is a powerful new tool to determine the specific contribution of traction forces involved in cell adhesion mediated by α5β1- and αvβ3-integrins. Cells adherent via α5β1-integrins have a tendency to exert higher maximum forces than cells adhering via αvβ3-integrins.

© 2013 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KEYWORDS:

cell adhesion; integrin; micropillar; peptidomimetics; traction force

PMID:
23913640
[PubMed - indexed for MEDLINE]
PMCID:
PMC3915041
Free PMC Article
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