Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Phys Anthropol. 2013 Sep;152(1):140-4. doi: 10.1002/ajpa.22313. Epub 2013 Jul 30.

Brief communication: Effect of nomadic subsistence practices on lactase persistence associated genetic variation in Kuwait.

Author information

  • 1Leverhulme Center for Human Evolutionary Studies, University of Cambridge, Cambridge, CB2 1QH, UK.

Abstract

Lactase persistence (LP)-the ability to digest lactose in adulthood-is paradigmatic of Holocenic dietary change affecting the evolutionary trajectory of specific populations. Kuwait represents one location of high LP where the variation in associated genomic regions has not been examined. Here, we present new sequence data from a 427 bp amplicon 14 kb upstream of the LCT (lactase) gene for two Bedouin tribal populations, the Ajman and Mutran. We estimate the frequency of known LP associated alleles and discuss the impact of nomadic-pastoralism on the associated genetic variation. We observe high frequency (56% on average) of the -13,915*G allele in both tribes, which is consistent with the high prevalence of LP in Kuwait. Whilst LP associated alleles occur in Kuwait at a similar frequency to other regional populations, we suggest that the -13,915*G allele frequency among the Kuwaiti Bedouin may be higher than among non-Bedouin Kuwaitis, possibly due to greater historical reliance on milk consumption or genetic drift.

Copyright © 2013 Wiley Periodicals, Inc.

KEYWORDS:

Bedouin; genetics; lactose tolerance; nomadic-pastoralism

PMID:
23913618
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk