Immunol Lett. 1990 Jul;24(4):247-51.

Increased expression of alkaline phosphatase activity in stimulated B lymphocytes by muramyl dipeptide.

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CNRS URA 1116, Institut de Biochimie, Université Paris-Sud, Orsay, France.

Abstract

We have recently shown that the synthetic immunomodulator muramyl dipeptide (MDP) acts on murine B lymphocytes. It synergizes with interleukin 2 and interleukin 4 to stimulate, respectively, the differentiation and the proliferation of B cells. In the present study, MDP was shown to increase the proliferation of B cells stimulated by lipopolysaccharide (LPS). Moreover, the expression of alkaline phosphatase activity induced by LPS was markedly enhanced by MDP. These effects were time- and dose-dependent. The present report suggests that the biochemical mechanism by which MDP exerts its effects may involve protein phosphorylation-dephosphorylation pathways.

PMID:: 2391133; [PubMed - indexed for MEDLINE]

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Muramyl dipeptide (MDP) synergizes with interleukin 2 and interleukin 4 to stimulate, respectively, the differentiation and proliferation of B cells. [Cell Immunol. 1990]
Muramyl dipeptide (MDP) synergizes with interleukin 2 and interleukin 4 to stimulate, respectively, the differentiation and proliferation of B cells.
Souvannavong V, Brown S, Adam A. Cell Immunol. 1990 Mar; 126(1):106-16.
[The stimulating action of lipopolysaccharide and muramyl dipeptide on the activation of mononuclear cells in human peripheral blood by recombinant interleukin-2 in vitro]. [Biull Eksp Biol Med. 1988]
[The stimulating action of lipopolysaccharide and muramyl dipeptide on the activation of mononuclear cells in human peripheral blood by recombinant interleukin-2 in vitro].
Rakhmilevich AL, Pelevina MA, Artsimovich NG, Fuks BB. Biull Eksp Biol Med. 1988 Dec; 106(12):698-701.
The synthetic immunomodulator muramyl dipeptide (MDP) can stimulate activated B cells. [Mol Immunol. 1988]
The synthetic immunomodulator muramyl dipeptide (MDP) can stimulate activated B cells.
Souvannavong V, Brown S, Adam A. Mol Immunol. 1988 Apr; 25(4):385-91.
[Increasing the sensitivity of murine splenic cells to interleukin-2 after in vivo exposure to lipopolysaccharide, muramyl dipeptide and concanavalin A]. [Antibiot Khimioter. 1989]
[Increasing the sensitivity of murine splenic cells to interleukin-2 after in vivo exposure to lipopolysaccharide, muramyl dipeptide and concanavalin A].
Rakhmilevich AL, Obernikhin SS, Rakhimova MS. Antibiot Khimioter. 1989 Nov; 34(11):839-41.
Differential regulation of surface immunoglobulin expression by various muramyl dipeptides in a murine pre-B cell line. [Immunol Lett. 1995]
Differential regulation of surface immunoglobulin expression by various muramyl dipeptides in a murine pre-B cell line.
Cohen LY, Parant MA. Immunol Lett. 1995 Mar; 45(3):210-4.

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Cited by 1 PubMed Central article

Interleukin-5 increases the expression of alkaline phosphatase activity in murine B lymphocytes. [Immunology. 1992]
Interleukin-5 increases the expression of alkaline phosphatase activity in murine B lymphocytes.
Souvannavong V, Brown S, Adam A. Immunology. 1992 Jul; 76(3):505-7.

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Increased expression of alkaline phosphatase activity in stimulated B lymphocytes by muramyl dipeptide.

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