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Head Neck Pathol. 2014 Jun;8(2):198-203. doi: 10.1007/s12105-013-0482-8. Epub 2013 Aug 2.

Kimura disease of the epiglottis: a case report and review of literature.

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  • 1Department of Pathology, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho Fukakusa Fushimi-ku, Kyoto-shi, Kyoto, 612-8555, Japan,


Kimura disease (KD) affecting an unusual site is a diagnostic challenge. We report herein the case of a 62-year-old Japanese woman who presented with swelling of the epiglottis, resulting in airway narrowing. Microscopically, biopsied and resected specimens both revealed lymphoid proliferation of a reactive immunophenotype, accompanied by vascular proliferation, eosinophilic infiltration, and stromal sclerosis. Adjunctive immunohistochemistry with immunoglobulin E in addition to laboratory and histological findings led us to seriously consider a diagnosis of KD. The patient underwent surgical removal with postoperative steroid therapy and has no evidence of recurrence. Our experience suggests that KD is potentially fatal as well as showing difficulty in the histological diagnosis when occurring in the upper respiratory tract, such as the epiglottis. A literature review disclosed that our case is the 11th case so far reported in this location, and that KD of the epiglottis did not show any male preponderance, as seen in other places.

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