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Hepatol Res. 2014 Oct;44(10):E54-62. doi: 10.1111/hepr.12213. Epub 2013 Aug 27.

Association of tyrosine with insulin resistance in hepatitis C virus-related chronic liver disease.

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  • 1Departments of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Japan.



Insulin resistance (IR) increases during the early stages of hepatitis C virus (HCV)-related chronic liver disease and is a sign of poor prognosis as well as a risk factor for hepatic fibrosis and hepatocellular carcinoma. We aimed to determine the factors affecting IR in HCV-related chronic liver disease.


We retrospectively examined 71 patients with HCV-related chronic liver disease and analyzed various parameters, including amino acids, as possible predictors of IR. IR was assessed using the Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR). Amino acids were assayed by examining branched-chain amino acids (BCAA), tyrosine level, and the ratio of BCAA to tyrosine level (BTR).


HOMA-IR was significantly correlated with body mass index, platelet count, prothrombin time, hemoglobin, total bilirubin, total protein, albumin, total cholesterol, fasting glucose, BTR (r = -0.46, P = 0.0001) and tyrosine (r = 0.55, P < 0.0001). However, BCAA were not significantly correlated with HOMA-IR (r = -0.21, P = 0.082). In multivariate analysis, only two factors were identified as independent parameters contributing to a HOMA-IR of 2.5 or more: total cholesterol (odds ratio [OR], 6.511; 95% confidence interval [95% CI], 1.554-27.284; P = 0.010) and tyrosine (OR, 4.839; 95% CI, 1.087-21.549; P = 0.039).


Serum tyrosine levels may be associated with IR in patients with HCV-related chronic liver disease.

© 2013 The Japan Society of Hepatology.


chronic hepatitis; hepatic fibrosis; hepatitis C virus; insulin resistance; liver cirrhosis; tyrosine

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