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J Virol. 2013 Oct;87(19):10912-5. doi: 10.1128/JVI.01839-13. Epub 2013 Jul 31.

AIDS alters the commensal plasma virome.

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  • 1Blood Systems Research Institute, San Francisco, California, USA.

Abstract

We compared the plasma viromes of HIV-infected subjects with low versus high CD4(+) T cell counts from the United States and Uganda by using deep sequencing and detected HIV, hepatitis C virus, hepatitis B virus, GB virus C, anellovirus, and human endogenous retrovirus (HERV) reads. An increase in the proportion of reads for anelloviruses, a family of highly prevalent and genetically diverse human viruses, was seen in subjects with AIDS from both countries. The proportion of endogenous human retrovirus reads was increased in AIDS subjects from Uganda but not the United States. Progression to AIDS is therefore associated with changes in the plasma concentration of commensal viruses.

PMID:
23903845
[PubMed - indexed for MEDLINE]
PMCID:
PMC3807392
Free PMC Article
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