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J Gerontol A Biol Sci Med Sci. 2014 Mar;69(3):363-70. doi: 10.1093/gerona/glt100. Epub 2013 Jul 31.

Bed rest worsens impairments in fat and glucose metabolism in older, overweight adults.

Author information

  • 1Center for Alaska Native Health Research, Institute of Arctic Biology, 311 Irving I, Box 757000, University of Alaska Fairbanks, Fairbanks, AK 99775-7000. rcoker@alaska.edu.

Abstract

BACKGROUND:

The effects of bed rest on the dysregulation of fatty acid and glucose metabolism have not been addressed in the older population.

OBJECTIVE:

We examined the effect of 10 days of bed rest on fatty acid kinetics and hepatic and peripheral insulin resistance in aging.

METHODS:

We utilized an octreotide, basal glucagon replacement, multistage insulin infusion, and the concomitant infusion of [6,6 (2)H₂]glucose to derive insulin-mediated suppression of glucose production and insulin-stimulated glucose disposal in nine older, overweight individuals (body mass index 28.1 ± 1.7 kg m(-2); 39.9% ± 1.9% fat). During the multistage insulin infusion, we also infused [1-(13)C]palmitate to examine free fatty acid rate of appearance (R(a)).

RESULTS:

Body weight, % body fat, and energy metabolism did not change with bed rest. There was a significant decrease (-2291 ± 316 cm(3)) in visceral fat, and no change in abdominal subcutaneous fat with bed rest. Insulin-mediated suppression of glucose production was modest prior to bed rest and was further reduced (>15% ± 2%) by bed rest. There was also a minor decrease in the insulin-mediated suppression of free fatty acid R(a) after bed rest and, as a consequence, a small variation in plasma free fatty acid from pre- to post-bed rest in the first stage of the multistage insulin infusion. There was also a significant bed rest-induced decline (>2.0 ± 0.6 mg kg FFM(-1) min(-1)) in insulin-stimulated glucose disposal.

CONCLUSIONS:

Preexisting impairments in insulin sensitivity are worsened by bed rest and seem linked to alterations in the regulation of free fatty acid in older, overweight individuals.

KEYWORDS:

Hospitalization; Inactivity; Metabolic disease.

PMID:
23902932
[PubMed - indexed for MEDLINE]
PMCID:
PMC3976140
[Available on 2015/3/1]
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