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BMC Neurosci. 2013 Jul 31;14:78. doi: 10.1186/1471-2202-14-78.

Wave propagation of cortical population activity under urethane anesthesia is state dependent.

Author information

  • 1Leibniz-Institute for Neurobiology, 39118 Magdeburg, Germany.

Abstract

BACKGROUND:

Propagating waves of excitation have been observed extensively in the neocortex, during both spontaneous and sensory-evoked activity, and they play a critical role in spatially organizing information processing. However, the state-dependence of these spatiotemporal propagation patterns is largely unexplored. In this report, we use voltage-sensitive dye imaging in the rat visual cortex to study the propagation of spontaneous population activity in two discrete cortical states induced by urethane anesthesia.

RESULTS:

While laminar current source density patterns of spontaneous population events in these two states indicate a considerable degree of similarity in laminar networks, lateral propagation in the more active desynchronized state is approximately 20% faster than in the slower synchronized state. Furthermore, trajectories of wave propagation exhibit a strong anisotropy, but the preferred direction is different depending on cortical state.

CONCLUSIONS:

Our results show that horizontal wave propagation of spontaneous neural activity is largely dependent on the global activity states of local cortical circuits.

PMID:
23902414
[PubMed - indexed for MEDLINE]
PMCID:
PMC3733618
Free PMC Article
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