Send to:

Choose Destination
See comment in PubMed Commons below
Prog Mol Biol Transl Sci. 2013;119:283-323. doi: 10.1016/B978-0-12-396971-2.00010-5.

Health consequences of circadian disruption in humans and animal models.

Author information

  • 1Department of Neurobiology, Morehouse School of Medicine, Atlanta, Georgia, USA.


Daily rhythms in behavior and physiology are programmed by a hierarchical collection of biological clocks located throughout the brain and body, known as the circadian system. Mounting evidence indicates that disruption of circadian regulation is associated with a wide variety of adverse health consequences, including increased risk for premature death, cancer, metabolic syndrome, cardiovascular dysfunction, immune dysregulation, reproductive problems, mood disorders, and learning deficits. Here we review the evidence for the pervasive effects of circadian disruption in humans and animal models, drawing from both environmental and genetic studies, and identify questions for future research.

© 2013, Elsevier Inc. All Rights Reserved.


Circadian; Clock gene mutants; Jetlag; Shift work

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk