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Acta Gastroenterol Belg. 2013 Jun;76(2):246-50.

Increased liver stiffness values in patients with heart failure.

Author information

  • 1Unidad de Hepatología. Departamento de Medicina Interna. Clinica Universidad de Navarra, Navarra, Spain. falegre@unav.es

Abstract

BACKGROUND:

Liver stiffness has been claimed to be increased in patients with heart failure.

AIMS:

To determine the magnitude of this increase in liver stiffness, and to clarify whether it is related to the degree of heart failure or not.

METHODS:

Twenty-six patients were prospectively collected, and divided in groups CHF (those with compensated chronic heart failure) and AHF (those with acute decompensated heart failure). Patients underwent routine blood chemistries, pro-BNP determination, echocardiography and transient elastography during outpatient care (group CHF) or at hospital admission (group AHF). Blood chemistries, pro-BNP and transient elastography were repeated in patients in group AHF before being discharged.

RESULTS:

Correlation between liver stiffness and pro-BNP levels was statistically significant (Rho = 0.747, p = 0.001). Patients in group CHF had lower values of liver stiffness and pro-BNP when compared with patients in group AHF at admission. Median liver stiffness and pro-BNP values were 6.5 vs 14.4 kPa (p = 0.009) and 1511 vs 3535 pg/ml (p = 0.025) respectively. After clinical compensation, liver stiffness decreased in all patients in group AHF. Liver stiffness was 14.4 kPa at admission and 8.2 kPa at discharge (p = 0.008). Pro-BNP values also decreased from a median of 3535 pg/ml to a median of 1098 pg/ml (p = 0.025).

CONCLUSIONS:

Patients with heart failure have increased liver stiffness, that appears to be related with the severity of heart failure.

PMID:
23898564
[PubMed - indexed for MEDLINE]
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