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J Magn Reson Imaging. 2014 May;39(5):1287-93. doi: 10.1002/jmri.24253. Epub 2013 Jul 29.

Simultaneous acquisition of T1ρ and T2 quantification in knee cartilage: repeatability and diurnal variation.

Author information

  • 1Musculo-skeletal Quantitative Imaging Research (MQIR), Department of Radiology, University of California, San Francisco (UCSF), San Francisco, California, USA.

Abstract

PURPOSE:

To develop a robust sequence that combines T1ρ and T2 quantifications and to examine the in vivo repeatability and diurnal variation of T1ρ and T2 quantifications in knee cartilage.

MATERIALS AND METHODS:

Six healthy volunteers were scanned in the morning and afternoon on 2 days using a combined T1ρ and T2 quantification sequence developed in this study. Repeatability of T1ρ and T2 quantification was estimated using root-mean-square coefficients-of-variation (RMS-CV). T1ρ and T2 values from morning scans were compared to those from afternoon scans using paired t-tests.

RESULTS:

The overall RMS-CV of in vivo T1ρ and T2 quantification was 5.3% and 5.2%, respectively. The RMS-CV of am scans was 4.2% and 5.0% while the RMS-CV of pm scans was 6.0% and 6.3% for T1ρ and T2 , respectively. No significant difference was found between T1ρ or T2 values in the morning and in the afternoon.

CONCLUSION:

A sequence that combines T1ρ and T2 quantification with scan time less than 10 minutes and is robust to B0 and B1 inhomogeneity was developed with excellent repeatability. For a cohort with low-level daily activity, although no significant diurnal variation of cartilage MR relaxation times was observed, the afternoon scans had inferior repeatability compared to morning scans.

Copyright © 2013 Wiley Periodicals, Inc.

KEYWORDS:

T1ρ; T2; cartilage degeneration; diurnal variation; repeatability

PMID:
23897756
[PubMed - indexed for MEDLINE]
PMCID:
PMC3844010
Free PMC Article
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