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Am J Clin Pathol. 2013 Aug;140(2):253-7. doi: 10.1309/AJCPJEFPNTMM3KSH.

Correlation between dysplastic lineage and type of cytopenia in myelodysplastic syndromes patients with refractory anemia according to the FAB classification.

Author information

  • 1Department of Hemato-Oncology, Saitama International Medical Center, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan. amatsu@saitama-med.ac.jp

Abstract

OBJECTIVES:

To analyze the correlation between dysplastic lineage and type of cytopenia in myelodysplastic syndromes.

METHODS:

We analyzed the correlation between dysplasia and cell count using the data set of our previous morphologic study.

RESULTS:

There were no correlations between dysgranulopoiesis of 10% or more and absolute neutrophil count (ANC). Similarly, hyposegmented mature neutrophils (Pelger) of 10% or more were not related to ANC. Interestingly, the platelet count of patients with dysmegakaryopoiesis (dys Mgk) was higher than that of patients without dys Mgk (dys Mgk ≥10% vs <10%, P = .08; dys Mgk ≥40% vs <40%, P = .02; micromegakaryocytes ≥10% vs <10%, P = .004).

CONCLUSIONS:

Since low cell counts did not correlate with the presence of dysplastic features, we suggest that dysplastic features do not directly relate to apoptosis.

KEYWORDS:

Cytopenia; Dysplastic features; Myelodysplastic syndromes; WHO classification

PMID:
23897263
[PubMed - indexed for MEDLINE]
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