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Antimicrob Agents Chemother. 2013 Oct;57(10):5178-80. doi: 10.1128/AAC.01244-13. Epub 2013 Jul 29.

Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection.

Author information

  • 1Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Jena, Germany.

Abstract

The pathology of vulvovaginal candidiasis (VVC) caused by Candida albicans is associated with a nonprotective inflammatory response and is frequently treated with clotrimazole. We investigated the mechanisms by which clotrimazole resolves VVC. Low levels of clotrimazole, which do not block fungal growth, inhibit expression of a "danger response" transcription factor, c-Fos, block production of proinflammatory cytokines, and inhibit neutrophil infiltration to the site of infection.

PMID:
23896471
[PubMed - indexed for MEDLINE]
PMCID:
PMC3811401
Free PMC Article
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