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Clin Neurophysiol. 2014 Jan;125(1):148-53. doi: 10.1016/j.clinph.2013.06.184. Epub 2013 Jul 26.

Positive auditory cortical responses in patients with absent brainstem response.

Author information

  • 1Laboratory of Rehabilitative Auditory Science, Tohoku University Graduate School of Biomedical Engineering, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan; Department of Audiology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan; Department of Otolaryngology-Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. Electronic address: kawase@orl.med.tohoku.ac.jp.
  • 2Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan; MEG Laboratory, Kohnan Hospital, 4-20-1 Nagamachi-minami, Taihaku-ku, Sendai 982-8523, Japan.
  • 3Department of Otolaryngology-Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
  • 4Department of Epileptology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan; Department of Electromagnetic Neurophysiology, Smart Ageing International Research Center, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan.
  • 5Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan.

Abstract

OBJECTIVE:

To compare the detectability of the different auditory evoked responses in patients with retrocochlear lesion.

METHODS:

The 40-Hz auditory steady state response (ASSR) and the N1m auditory cortical response were examined by magnetoencephalography in 4 patients with vestibular schwannoma, in whom the auditory brainstem response (ABR) was absent.

RESULTS:

Apparent N1m responses were observed despite total absence of the ABR or absence except for small wave I in all patients, although the latency of N1m was delayed in most patients. On the other hand, clear ASSFs could be observed only in one patient. Very small 40-Hz ASSFs could be detected in 2 patients (amplitude less than 1fT), but no apparent ASSFs were observed in one patient, in whom maximum speech intelligibility was extremely low and the latency of N1m was most prolonged.

CONCLUSION:

The N1m response and 40-Hz ASSR could be detected in patients with absent ABR, but the N1m response appeared to be more detectable than the 40-Hz ASSR.

SIGNIFICANCE:

Combined assessment with several different evoked responses may be useful to evaluate the disease conditions of patients with retrocochlear lesions.

Copyright © 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Auditory evoked field; Auditory steady state response; Magnetoencephalography; N1m; Vestibular schwannoma

PMID:
23895952
[PubMed - indexed for MEDLINE]
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