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Angew Chem Int Ed Engl. 2013 Sep 2;52(36):9388-98. doi: 10.1002/anie.201302365. Epub 2013 Jul 26.

4-Hydroxyphenylpyruvate dioxygenase inhibitors in combination with safeners: solutions for modern and sustainable agriculture.

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  • 1Small Molecules Research, Bayer CropScience AG, Industriepark Höchst, 65926 Frankfurt a.M., Germany.


Inhibitors of 4-hydroxyphenylpyruvate dioxygenase (HPPD) prevent plant carotenoid pigment formation, which in turn leads to chlorophyll degradation. This "bleaching" herbicide mode of action provides weed-control products for various crops, such as rice, corn, and cereals. Combinations with suitable safeners allow the full exploitation of the potential of this compound class to selectively control major weed problems, including rapidly increasing cases of resistance against other important herbicide classes.

Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


HPPD inhibitors; crop protection agents; drug discovery; herbicides; safeners

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