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Adv Mater. 2013 Sep 25;25(36):5060-6. doi: 10.1002/adma.201300526. Epub 2013 Jul 29.

Rapidly-dissolvable microneedle patches via a highly scalable and reproducible soft lithography approach.

Author information

  • 1Department of Chemistry, University of North Carolina at Chapel Hill, CB #3290, Caudill Labs, Chapel Hill, NC, 27599.

Abstract

Microneedle devices for transdermal drug delivery have recently become an attractive method to overcome the diffusion-limiting epidermis and effectively transport therapeutics to the body. Here, we demonstrate the fabrication of highly reproducible and completely dissolvable polymer microneedles on flexible water-soluble substrates. These biocompatible microneedles (made by using a soft lithography process known as PRINT) showed efficacy in piercing both murine and human skin samples and delivering a fluorescent drug surrogate to the tissue.

© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KEYWORDS:

PRINT; drug delivery; microneedles; microprojections; soft lithography

PMID:
23893866
[PubMed]
PMCID:
PMC4262250
Free PMC Article
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